Cytogenetic anomalies in Multiple Myeloma patients:A single center study.

  • Süreyya Bozkurt Department of Medical Biology, Faculty of Medicine, Istinye University, Istanbul, Turkey
  • Yahya Büyükaşık Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Haluk Demiroğlu Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Elifcan Aladağ Karakulak Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Müfide Okay Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Ayşe Karataş Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Salih Aksu Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • İbrahim Haznedaroğlu Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Nilgün Sayınalp Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Osman Özcebe Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey
  • Hakan Göker Department of Internal Medicine, Division of Hematology, Hacettepe University, Ankara, Turkey

Abstract

Conventional karyotyping in the patients with Multiple myeloma (MM) is very important. Because chromosomal abnormalities which detected in these patients have diagnostic and prognostic value. In this retrospective study we aim to evaluate cytogenetic abnormalities in 133 MM patients which diagnosed at the Hematology Department of Hacettepe University. Samples were treated with trypsin and stained with Giemsa (GTG banding). 20 metaphases of each patient were examined and karyotypes were formed. Cytogenetic results of the patient’s bone marrow samples were not obtained in 19 patients, while in 116 patients karyotyping was performed. Among of these 116 patients showed that 80 patients had normal karyotpe while 34 patients had abnormal karyotypes. Both numerical and structural chromosomal anomalies were detected in patients with abnormal karyotype. Numerical and structural anomalies of chromosomes 1, 9, 16 and 13 were detected most frequently among these complex karyotypes. The anomalies we found in our patient group were consistent with the literature.

Published
2019-06-26
How to Cite
BOZKURT, Süreyya et al. Cytogenetic anomalies in Multiple Myeloma patients:A single center study.. Genetics & Applications, [S.l.], v. 3, n. 1, p. 51-56, june 2019. ISSN 2566-431X. Available at: <http://www.genapp.ba/index.php/genapp/article/view/87>. Date accessed: 21 sep. 2019. doi: https://doi.org/10.31383/ga.vol3iss1pp51-56.
Section
Research Articles