Lead and cadmium induced cytotoxic and genotoxic effects on HL-60 and Jurkat cell lines

  • Esmeralda Dautović University of Tuzla, Faculty of Pharmacy, Tuzla, Bosnia and Herzegovina
  • Maida Šljivić Husejnović University of Tuzla, Faculty of Pharmacy, Tuzla, Bosnia and Herzegovina
  • Martina Bergant University of Nova Gorica, Laboratory for Environmental and Life Sciences, Nova Gorica, Slovenia
  • Damir Sabitović University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina
  • Nahida Srabović University of Tuzla, Faculty of Pharmacy, Tuzla, Bosnia and Herzegovina
  • Aida Smajlović University of Tuzla, Faculty of Pharmacy, Tuzla, Bosnia and Herzegovina
  • Lejla Begić University of Tuzla, Faculty of Pharmacy, Tuzla, Bosnia and Herzegovina
  • Adaleta Softić University of Tuzla, Faculty of Pharmacy, Tuzla, Bosnia and Herzegovina

Abstract

Humans are exposed to a mixture of toxic heavy metals in the environment. Because of the lack of information on the toxicity of their mixtures, in this study, two common heavy metals, lead and cadmium, were introduced individually and as mixtures in HL-60 and JURKAT cell lines for 24 hours. Our experimental results have shown that these two heavy metals induced cytotoxic and genotoxic effects in both cell lines. Also, cadmium exhibited a higher cytotoxic and genotoxic potential than lead. The cytotoxicity data of single metals were used to determine the mixtures interaction profile by using the effect additivity method. Metal mixtures showed synergistic effect in HL-60 cells and antagonistic effect in JURKAT cells, compared to individual metals. The combined effects should be considered in the risk assessment of heavy metal co-exposure and potency. 


 

Published
2019-06-26
How to Cite
DAUTOVIĆ, Esmeralda et al. Lead and cadmium induced cytotoxic and genotoxic effects on HL-60 and Jurkat cell lines. Genetics & Applications, [S.l.], v. 3, n. 1, p. 57-64, june 2019. ISSN 2566-431X. Available at: <http://www.genapp.ba/index.php/genapp/article/view/88>. Date accessed: 22 july 2019. doi: https://doi.org/10.31383/ga.vol3iss1pp57-64.
Section
Research Articles