Triggering apoptosis in tumors: an overview of potential approaches in treatment of leukemia

  • Maida Hadžić University of Sarajevo – Institute for Genetic Engineering and Biotechnology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
  • Sanin Haverić University of Sarajevo – Institute for Genetic Engineering and Biotechnology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
  • Lejla Pojskić University of Sarajevo – Institute for Genetic Engineering and Biotechnology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina

Abstract

Apoptosis, as a well-studied process of a programmed cell death, is essential for the maintenance of cell homeostasis and integrity of organisms. This process occurs normally during development and aging and it is a balance of the sustainability of the tissue cell population. In addition, apoptosis also occurs as a defensive mechanism such as an immune response or after cell damage as a consequence of a pathological condition or the action of harmful agents. Apoptotic activation tends to be less responsive with aging, causing accumulation of non-functional cells and pathological changes such are degenerative diseases or tumor transformation. This overview aims to provide summarized facts about different approaches of apoptosis research, targeting and regulation in tumors especially in leukemic cells as a way of pharmacological manipulation with a potential therapeutic benefit.

Published
2019-06-26
How to Cite
HADŽIĆ, Maida; HAVERIĆ, Sanin; POJSKIĆ, Lejla. Triggering apoptosis in tumors: an overview of potential approaches in treatment of leukemia. Genetics & Applications, [S.l.], v. 3, n. 1, p. 3-13, june 2019. ISSN 2566-431X. Available at: <http://www.genapp.ba/index.php/genapp/article/view/94>. Date accessed: 21 sep. 2019. doi: https://doi.org/10.31383/ga.vol3iss1pp3-13.
Section
Reviews